Replication-selective virotherapy for cancer: Biological principles, risk management and future directions

Authors
Kirn, D Martuza, RL Zwiebel, J
Citation
D. Kirn et al., Replication-selective virotherapy for cancer: Biological principles, risk management and future directions, NAT MED, 7(7), 2001, pp. 783-789
Citations number
78
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
NATURE MEDICINE
ISSN journal
10788956 → ACNP
Volume
7
Issue
7
Year of publication
2001
Pages
783 - 789
Database
ISI
SICI code
1078-8956(200107)7:7<783:RVFCBP>2.0.ZU;2-S
Abstract
In the search for novel cancer therapies that can be used in conjunction wi th existing treatments, one promising area of research is the use of viral vectors and whole viruses. This review describes the underlying biological principles and current status of the field, outlines approaches for improvi ng clinical effectiveness and discusses the unique safety and regulatory is sues surrounding viral therapies.