Reversal of CSF positivity for JC virus genome by cidofovir in a patient with systemic lupus erythematosus and progressive multifocal leukoencephalopathy

Authors
Salmaggi, A Maccagnano, E Castagna, A Zeni, S Fantini, F Cinque, P Savoiardo, M
Citation
A. Salmaggi et al., Reversal of CSF positivity for JC virus genome by cidofovir in a patient with systemic lupus erythematosus and progressive multifocal leukoencephalopathy, NEUROL SCI, 22(1), 2001, pp. 17-20
Citations number
15
Categorie Soggetti
Neurology
Journal title
NEUROLOGICAL SCIENCES
ISSN journal
15901874 → ACNP
Volume
22
Issue
1
Year of publication
2001
Pages
17 - 20
Database
ISI
SICI code
1590-1874(200102)22:1<17:ROCPFJ>2.0.ZU;2-T
Abstract
We report the case of a 36-year-old woman affected by systemic lupus erythe matosus who developed rapidly progressive multifocal leukoencephalopathy. C idofovir therapy induced disappearance of JC virus genome from the cerebros pinal fluid and stabilization of the MRI picture. Despite the fatal outcome after a few months of disease, cidofovir treatment deserves further testin g as single antiviral therapy in HIV-negative PML patients.