Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X

Authors
Hagerman, RJ Leehey, M Heinrichs, W Tassone, F Wilson, R Hills, J Grigsby, J Gage, B Hagerman, PJ
Citation
Rj. Hagerman et al., Intention tremor, parkinsonism, and generalized brain atrophy in male carriers of fragile X, NEUROLOGY, 57(1), 2001, pp. 127-130
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
57
Issue
1
Year of publication
2001
Pages
127 - 130
Database
ISI
SICI code
0028-3878(20010710)57:1<127:ITPAGB>2.0.ZU;2-G
Abstract
The authors report five elderly men with the fragile X premutation who had a progressive action tremor associated with executive function deficits and generalized brain atrophy. These individuals had elevated fragile X mental retardation 1 gene (FMR1) messenger RNA and normal or borderline levels of FMR1 protein. The authors propose that elevations of FMR1 messenger RNA ma y be causative for a neurodegenerative syndrome in a subgroup of elderly me n with the FMR1 premutation.