Myopathy with tubulin-reactive crystalline inclusions

Authors
Vu, TH Hays, AP Tanji, K Younger, D Gundersen, GG Eastwood, A Braun, CW DiMauro, S Bonilla, E
Citation
Th. Vu et al., Myopathy with tubulin-reactive crystalline inclusions, NEUROLOGY, 57(1), 2001, pp. 149-152
Citations number
9
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
57
Issue
1
Year of publication
2001
Pages
149 - 152
Database
ISI
SICI code
0028-3878(20010710)57:1<149:MWTCI>2.0.ZU;2-S
Abstract
A 61-year-old man with muscle aches and persistently elevated serum creatin e kinase had aggregates of randomly oriented, rhomboidal or rectangular pro tein crystalline inclusions in the sarcoplasm of type II fibers. Immunochem ical studies showed strong reactivity of the inclusions to tubulin antibodi es, suggesting that these unique crystalline inclusions may be a consequenc e of altered synthesis, processing, or degradation of tubulin.