Chelation, activation, and proximity effects in the deprotection of dithianes with ZnBr2. Applications in the polyketide field

Authors
Vakalopoulos, A Hoffmann, HMR
Citation
A. Vakalopoulos et Hmr. Hoffmann, Chelation, activation, and proximity effects in the deprotection of dithianes with ZnBr2. Applications in the polyketide field, ORG LETT, 3(14), 2001, pp. 2185-2188
Citations number
24
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
14
Year of publication
2001
Pages
2185 - 2188
Database
ISI
SICI code
1523-7060(20010712)3:14<2185:CAAPEI>2.0.ZU;2-S
Abstract
[GRAPHICS] Double deprotection of dithiane aldol equivalents is feasible under mild co nditions with ZnBr2 and suitably placed MEM, BOM, and SEM groups which func tion as protecting, activating, and regiodirecting groups. The procedure is useful in natural product synthesis,