Efficient and practical synthesis of the A-ring precursor of 19-nor-1 alpha,25-dihydroxyvitamin D-3 and its C-13, or H-2-labeled derivative

Authors
Hanazawa, T Inamori, H Masuda, T Okamoto, S Sato, F
Citation
T. Hanazawa et al., Efficient and practical synthesis of the A-ring precursor of 19-nor-1 alpha,25-dihydroxyvitamin D-3 and its C-13, or H-2-labeled derivative, ORG LETT, 3(14), 2001, pp. 2205-2207
Citations number
22
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
14
Year of publication
2001
Pages
2205 - 2207
Database
ISI
SICI code
1523-7060(20010712)3:14<2205:EAPSOT>2.0.ZU;2-J
Abstract
[GRAPHICS] The A-ring precursor of 19-nor-1 alpha ,25-dihydroxyvitamin D-3 (1) and its C-13- or H-2-labeled derivative were efficiently synthesized from readily available, optically active 5-(tert-butyldimethylsilyloxy)-2-cyclohexenone (2) through a five step reaction in 68% overall yield.