Highly efficient synthesis of 1,1-difluoro-2-substituted-1,3-dienes and dienynes from gem-difluorohomoallenyl bromide via palladium-catalyzed cross-coupling reactions

Authors
Shen, QL Hammond, GB
Citation
Ql. Shen et Gb. Hammond, Highly efficient synthesis of 1,1-difluoro-2-substituted-1,3-dienes and dienynes from gem-difluorohomoallenyl bromide via palladium-catalyzed cross-coupling reactions, ORG LETT, 3(14), 2001, pp. 2213-2215
Citations number
37
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
14
Year of publication
2001
Pages
2213 - 2215
Database
ISI
SICI code
1523-7060(20010712)3:14<2213:HESO1A>2.0.ZU;2-I
Abstract
[GRAPHICS] A stable gem-difluoroallenylindium 1 is readily transformed to a potentiall y bifunctional electrophile 2, which can then undergo a transition-metal-pr omoted isomerization-cross coupling cascade to yield diene 3 and dienyne 4 in very high yields.