Objectives:To develop a simplified Therapeutic Intervention Scoring Sy
stem (TISS) based on the TISS-28 items and to validate the new score i
n an independent dat abase. Design: Retrospective statistical analysis
of a database and a prospective multicentre study. Setting: Developme
nt in the data base of the Foundation for Research on Intensive Care i
n Europe with external validation in 64 intensive care units (ICUs) of
11 European countries. Measurements and results: Development of NEMS
on a random sample of TISS-28 items, cross validation on another rando
m sample of TISS-28, and external validation of NEMS in comparison wit
h TISS-28 scored by two independent raters on the day of the visit to
the ICUs participating in an international study. Multivariable regres
sion techniques, Pearson's correlation, and paired sample t-tests were
used (significance at p < 0.05 level). Intraclass correlation, rate o
f agreement, and kappa statistics were used for interrater reliability
tests. The TISS-28 items were reduced to NEMS (9 items) in a random s
ample of 2000 records; the means of the two scores were no different:
TISS-28 26.23 +/- 10.38, NEMS 26.19 +/- 9.12, NS. Cross-validation in
a random sample of 996 records; mean TISS-28 26.13 +/- 10.38, NEMS 26.
17 +/- 9.38, NS; R-2 = 0.76. External validation on 369 pairs of TISS-
28 and NEMS has shown that the means of the two scores were no differe
nt: TISS-28 27.56 +/- 11.03, NEMS 27.02 +/- 8.98, NS; R-2 = 0.59. Reli
ability tests have shown an ''almost perfect'' interrater correlation.
Similar to studies correlating TISS with Simplified Acute Physiology
Score (SAPS)-I and/or Acute Physiology and Chronic Health Evaluation I
I scores, the value of NEMS scored on the first day accounts for 30.4
% of the variation of SAPS-II score. Conclusions: NEMS is a suitable t
herapeutic index to measure nursing workload at the ICU level. The use
of NEMS is indicated for: (a) multicentre ICU studies; (b) management
purposes in the general (macro) evaluation and comparison of workload
at the ICU level; (c) the prediction of workload and planning of nurs
ing staff allocation at the individual patient level.