M. Okita et al., Effect of arachidonic acid-rich oil on lipids and arachidonate metabolitesin ethanol-treated rats, PROS LEUK E, 64(4-5), 2001, pp. 273-279
Citations number
27
Categorie Soggetti
Cell & Developmental Biology
Journal title
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
The effects of dietary arachidonic acid-rich oil (AAoil) on lipids and arac
hidonate metabolites in the liver and plasma were evaluated in ethanol-trea
ted rats. Rats were fed a purified diet containing 10% weight of lard or AA
oil for 14 days. Ethanol was administered by gavage at a single daily dose
of 3 g/kg body weight. Comparing with the lard group, a decrease was observ
ed in liver fatty vacuoles in the AAoil group. Plasma 6-keto-prostaglandin
(PG) F1 alpha and thromboxane (TX) B-2 levels and the 6-keto-PGF1 alpha /TX
B2 ratio increased significantly in the AAoil group. Liver 6-keto-PGF1 alph
a also increased but not leukotriene B-4 in the AAoil group. In the phospho
lipid fraction of liver tissue, plasma and red blood cells, arachidonic aci
d (20:4n-6) and docosatetraenoic acid (22:4n-6) increased and oleic acid (1
8:1n-9) and linoleic acid (18:2n-6) decreased significantly in the AAoil gr
oup compared with the lard group. These observations suggest that AAoil sup
plementation reduces liver injury of ethanol-treated rats, although longer
observation will be necessary for confirmation. (C) 2001 Harcourt Publisher
s Ltd.