Jsa. Green et al., An investigation into the spatial relationship between prostate intraepithelial neoplasia and cancer, PROSTATE C, 4(2), 2001, pp. 97-100
The distribution of high grade prostate intraepithelial neoplasia (PIN) and
cancer was analysed in 18 separate areas from 89 radical prostatectomy spe
cimens that had been sectioned and digitally imaged. When the occurrence of
each type of pathology was summated a predilection was demonstrated for bo
th pathologies in the apex of the prostate and a linear relationship was fo
und between the frequency of cancer and high grade PIN (r(2) = 0.744, P < 0
.05). This relationship was strongest at the apex (r(2) = 0.621, P < 0.005)
, lower in the midgland (r(2) = 0.828, P < 0.05) and bordered on significan
ce at the base (r(2) = 0.621, P < 0.063). These results support the theory
that cancer could obliterate high grade PIN as it over grows the areas once
occupied by PIN.