Proteome analysis of the common human pathogen Helicobacter pylori

The common human pathogen Helicobacter pylori is the major cause of gastric and duodenal ulcers. Based on the complete genome sequences of two indepen dent isolates more than 1800 protein species have been resolved by two-dime nsional gel electrophoresis and more than 200 of them have been identified (http://www.mpiibberlin.mpg.de/2D-PAGE). Using these data, a large range of research areas including strain fingerprinting, protein composition and su bcellular localization, gene regulation, and pathogen-host interactions hav e been investigated. The results that have been obtained led to a more deta iled understanding of the Helicobacter biology and pathology and open furth er interesting fields for future work.