Complexation studies with Y-90 from a novel Sr-90-Y-90 generator

Some features of a novel Sr-90-Y-90 generator which employs supported liqui d membrane (SLM) to separate carrier-free Y-90 from Sr-90 present in the hi gh level waste of the spent fuel of reactor are described. After ascertaini ng the purity of Y-90 particularly with respect to Sr-90 breakthrough, its complexation was studied with a few oxo/aza donor Ligands, such as DTPA, ED TMP, DOTA, TETA and a cyclic phosphonate, CTMP. These studies were primaril y carried out to adjudge the quality of the Y-90 obtained from a novel Sr-9 0-Y-90 generator and ascertain its usability for labelling biomolecules suc h as antibodies and peptides. The DOTA complexes are most stable at 37 degr eesC in human serum; they appear to be ideal bifunctional chelating agent f or use in radioimmunotherapy with Y-90.