Mt. Barros et al., Bromine in methanol: An efficient reagent for the deprotection of the tert-butyldiphenylsilyl group, SYNLETT, (7), 2001, pp. 1146-1148
A selective reagent for the deprotection of a tert-butyl-diphenylsilyl (TBD
PS) ether in the presence of other protecting groups, using a solution of b
romine in methanol under reflux is presented. By extension, this reagent ha
s been introduced for the deprotection of TBDPS amines and esters and has a
lso shown good selectivity in the removal of a TBDMS ether in the presence
of a TBDPS one.