Bromine in methanol: An efficient reagent for the deprotection of the tert-butyldiphenylsilyl group

Authors
Barros, MT Maycock, CD Thomassigny, C
Citation
Mt. Barros et al., Bromine in methanol: An efficient reagent for the deprotection of the tert-butyldiphenylsilyl group, SYNLETT, (7), 2001, pp. 1146-1148
Citations number
12
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
SYNLETT
ISSN journal
09365214 → ACNP
Issue
7
Year of publication
2001
Pages
1146 - 1148
Database
ISI
SICI code
0936-5214(200107):7<1146:BIMAER>2.0.ZU;2-5
Abstract
A selective reagent for the deprotection of a tert-butyl-diphenylsilyl (TBD PS) ether in the presence of other protecting groups, using a solution of b romine in methanol under reflux is presented. By extension, this reagent ha s been introduced for the deprotection of TBDPS amines and esters and has a lso shown good selectivity in the removal of a TBDMS ether in the presence of a TBDPS one.