LiClO4-catalyzed one-pot synthesis of dihydropyrimidinones: An improved protocol for Biginelli reaction

Authors
Yadav, JS Reddy, BVS Srinivas, R Venugopal, C Ramalingam, T
Citation
Js. Yadav et al., LiClO4-catalyzed one-pot synthesis of dihydropyrimidinones: An improved protocol for Biginelli reaction, SYNTHESIS-S, (9), 2001, pp. 1341-1345
Citations number
27
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
00397881 → ACNP
Issue
9
Year of publication
2001
Pages
1341 - 1345
Database
ISI
SICI code
0039-7881(200107):9<1341:LOSODA>2.0.ZU;2-3
Abstract
Lithium perchlorate efficiently catalyzes the three-component condensation reaction of aldehyde, beta -keto ester and urea in refluxing acetonitrile t o afford the corresponding dihydropyrimidinones in high yields under neutra l conditional LiOTf is also found to be an efficient catalyst for the synth esis of dihydropyrimidinones from aldehyde, beta -keto eater and urea.