Single electron transfer approaches to the practical synthesis of aromaticand heterocyclic-CF2H derivatives

Authors
Dolbier, WR Medebielle, M Ait-Mohand, S
Citation
Wr. Dolbier et al., Single electron transfer approaches to the practical synthesis of aromaticand heterocyclic-CF2H derivatives, TETRAHEDR L, 42(29), 2001, pp. 4811-4814
Citations number
22
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
42
Issue
29
Year of publication
2001
Pages
4811 - 4814
Database
ISI
SICI code
0040-4039(20010716)42:29<4811:SETATT>2.0.ZU;2-5
Abstract
Single electron transfer (SET) approaches with organic reductants such as s odium hydroxymethanesulfinate (Rongalite((R))), sodium dithionite (regarded as precursors of sulfoxylate radical anion) and tetrakis(dimethylamino)eth ylene (TDAE) were employed for the reductive dehalogenation of a series of halogeno-difluoromethylated aromatics and heterocycles, and for the practic al synthesis of the corresponding difluoromethylated derivatives. (C) 2001 Elsevier Science Ltd. All rights reserved.