A classical inactivated vaccine induces protection against caprine herpesvirus 1 infection in goats

Eight goats were inoculated with an inactivated caprine herpesvirus 1 (CpHV -1) vaccine. Four unvaccinated goats were kept as controls. After 30 days, four of the eight goats were revaccinated. Fifty days after the first vacci nation the animals were divided into two groups (A and B) of six goats each (two goats vaccinated twice, two goats vaccinated once and two goats unvac cinated). The two groups were challenged with CpHV-1 intranasally (group A) or intravaginally (group B). After CpHV-1 challenge, the four control goat s showed the typical genital lesions, whereas all the vaccinated goats were fully protected against clinical signs. Protection against infection depen ded on the number of injections of vaccine and the route of challenge. (C) 2001 Elsevier Science Ltd. All rights reserved.