L. Goetsch et al., BBG2Na an RSV subunit vaccine candidate intramuscularly injected to human confers protection against viral challenge after nasal immunization in mice, VACCINE, 19(28-29), 2001, pp. 4036-4042
Respiratory syncytial virus (RSV) is a major respiratory pathogen responsib
le for severe pulmonary disease. We have developed a parenterally administe
red vaccine, BBG2Na, which is currently in a phase III clinical trial. BBG2
Na comprises residues 130-230 of RSV-A G protein (G2Na) fused to the BE car
rier protein. In this study, we show that BBG2Na can be delivered by the na
sal route and generates both mucosal and systemic antibody responses when c
o-administered with cholera toxin B or a newly described delivery system, z
wittergent 3-14. We found that nasal BBG2Na administration protects against
RSV challenge and does not induce lung immunopathology upon subsequent RSV
challenge. (C) 2001 Elsevier Science Ltd. All rights reserved.