AVASCULAR NECROSIS OF BONE FOLLOWING AN INTENSIFIED CHEMOTHERAPY REGIMEN INCLUDING HIGH-DOSE STEROIDS

We report the imaging findings and natural history of avascular necros is of bone (AVN) that developed following a chemotherapy regimen inclu ding high dose steroid treatment, All patients had acute lymphoblastic (ALL) or non-Hodgkin's lymphoma (NHL). Symptoms followed the high dos e steroid therapy and 28 joints in eight patients were involved, (11 k nees, seven hips, five shoulders and five ankles). Plain radiographs a t presentation were normal in most joints, whilst bone scintigraphy an d magnetic resonance imaging (MRI) mere positive, We believe that the development of AVN in these patients is most likely due to the high do se dexamethasone therapy as in all eight cases symptoms followed this stage of the regimen, Patients experiencing bone or joint pains while receiving high dose steroids as part of a chemotherapy regimen could b e investigated by bone scintigraphy but MRI is preferable as it is mor e sensitive and specific for AVN. In this series of patients multiple joints were involved and all the male patients proceeded rapidly from bone infarction to joint collapse, If the MRI appearances are typical, an early diagnosis of AVN can be made enabling therapeutic interventi ons to prevent joint collapse and its associated morbidity.