New insights into insulin resistance pathophysiology: How it affects glucose and lipid metabolism

Insulin resistance is a metabolic state encountered in many physiological a nd physiopathological conditions. Its pivotal effect on glucose and lipid m etabolism is increasingly recognised. Over the last few years, numerous mol ecular/intracellular pathways affected by this condition have been elucidat ed. The author reviews some recent findings underlying several major metabo lic abnormalities. An overview of current and future therapeutics is also p rovided.