Effect of moisturizers on skin susceptibility to irritants

Moisturizers are used for the treatment of dry and irritated skin. The bene fit of moisturizers when used on normal skin has recently been challenged, since an earlier study indicated that the increased hydration that follows long-term use of moisturizers on normal skin may facilitate penetration of irritants. The aim of the present study was to evaluate short-term use of 2 different moisturizers used on normal skin: cream A thigh lipid content) a nd B (moderate/low lipid content). Nineteen healthy volunteers applied the moisturizers on the upper arm/forearm 3 times daily for 5 days, while the o ther upper arm/forearm served as symmetrical control. The day after moistur izer treatment was stopped the skin was challenged with a patch test of sod ium lauryl sulphate. Skin reactions were evaluated by bioengineering measur ing methods and clinical scoring. Skin response to sodium lauryl sulphate w as increased on moisturizer-treated arms compared to controls for one of th e moisturizer (cream A), while this was not statistically significant for t he other moisturizer (cream B). Data confirm previous indications that some moisturizers when used on normal skin may increase skin susceptibitity to irritants.