Background. To assess whether hormonal treatment of endometriosis improves
quality of life for women with endometriosis.
Methods. In a prospective, randomized, double-blind, double-dummy study on
48 women with verified endometriosis, the pain pattern and quality of life
were registered before, during and after treatment with nafarelin or medrox
yprogesterone acetate. The distribution of the studied parameters were test
ed by means of a Skewness test. ANOVA analysis was used for normally distri
buted variables and Friedman's analysis and Mann-Whitney U-test for non nor
mally distributed variables.
Results. There was a difference between the 30 women who participated all t
hrough the study and the 18 who dropped out. It was noticeable that anxiety
-depression and sleep disturbances were significantly more common among the
drop outs. There was a significant reduction in symptom score during the s
tudy, without any significant difference between the treatment groups. The
sleep disturbances and anxiety-depression score improved significantly from
before treatment to the end of the follow-up, but the anxiety-depression s
core increased during the nafarelin treatment period. There was a statistic
ally significant improvement of paid working life in the nafarelin treated
group. All the other psyche-social parameters as well as emotional balance
improved during the study period without difference between groups.
Conclusion. When hormonal treatment is planned it is very important to take
into consideration previous psychosocial experiences of the patient. Facto
rs of importance for quality of life such as sleep disturbances and anxiety
-depression improved significantly after treatment with nafarelin or medrox
yprogesterone acetate.