Identification and comparison of eleven rhesus macaque chemokine receptors

Both simian and human immunodeficiency viruses (SIV and HIV) utilize chemok ine receptors, with or without CD4, as portals for entry into susceptible c ells. In this report, we present the cloning and comparison of 11 rhesus ma caque chemokine receptors and receptor-like proteins (CCR1, CCR2b, CCR3, CC R5, CCR8, CXCR4, STRL33, GPR1, GPR15, APJ, and CRAM-A/B), the human counter parts of which have been previously shown to be utilized by SIV for entry.