A nasal rinsing with isoosmotic Emser brine solution is able to reduce drug use in seasonal allergic rhinitis

We investigated the effects: of nasal rinsing with isoosmotic Emser brine s olution in adults suffering from seasonal allergic rhinitis. A total of 75 patients (40 femals, 35 males, aged 30 +/- 10.5 years) participated in this study and were treated oc or 2 - 4 weeks with systemical and/or topical an tihistamines, topical steroids, or vasoconstrictors as needed. Half of the patients additionally used Emser Salt rinsings with the nasal shower RhinoC are 1 - 2 times daily. Target parameters: were the use of antiallergic drug s, symptoms, and ECP and tryptase in nasal secretions as well as a semiquan titative determination of inflammatory cells in nasal cytology. In both gro ups, a significant reduction in symptoms was observed (both p < 0.0001) wit hout significant intergroup-differcnccs (p > 0.05). The intake of anti-alle rgic drugs, however, was more than 30% lower in the Emser Salt group compar ed to the controls (p <0.05). Also, the cell activation markers ECP and try ptase in nasal secretions were significantly reduced by both treatments (bo th p < 0.001) without intergroup-differences (p > 0.05). Similar results: w ere found for the reduction of eosinophils (both groups: p < 0.0001) and ma st cells (both groups: p <0.01). Again, there were no intergroup-difference s for the cellular parameters (all: p > 0.05). Nasal rinsing with Emser bri ne solution and the RhinoCare nasal shower was shown to be an effective adj uvant treatment for patients suffering from seasonal allergic rhinitis.