Successful pregnancy in a woman with Bloom syndrome

Bloom syndrome is a rare autosomal recessive disorder notable for increased chromosome fragility and an increased rate of somatic mutation. The clinic al manifestations include small stature, a characteristic dermatologic lesi on, and an excess incidence of malignancy. Fertility is generally reduced. A 19-year-old white woman with Bloom syndrome was successfully treated for preterm labor at 32 weeks' gestation, and ultimately delivered a healthy ma le infant at 35 weeks' gestation; Reports of pregnancy in women with Bloom syndrome are few. Despite reduced fertility, conception can occur, and wome n with Bloom syndrome should receive appropriate reproductive counseling to prevent unintended pregnancies and increased surveillance for preterm birt h. (C) 2001 Wiley-Liss, Inc.