A. Moraska et M. Fleshner, Voluntary physical activity prevents stress-induced behavioral depression and anti-KLH antibody suppression, AM J P-REG, 281(2), 2001, pp. R484-R489
Citations number
38
Categorie Soggetti
Physiology
Journal title
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
The current study addressed whether physical activity can buffer stress-ind
uced "behavioral depression" and immunosuppression. Adult, male Sprague-Daw
ley rats were housed with either a mobile (physically active) or immobile (
sedentary) running wheel and exposed to either stress (inescapable tail sho
ck) or no stress (home cage control). Voluntary wheel running began 4 wk be
fore stressor exposure. Immediately before stress, all rats were administer
ed an intraperitoneal injection of keyhole limpet hemocyanin (KLH; 200 mug)
, and anti-KLH Ig was measured weekly for 4 wk using ELISA. Prior physical
activity reduced the stress-induced behavioral depression and prevented the
stress-induced suppression of anti-KLH IgM and IgG(2a) antibodies. Anti-KL
H IgG(1) was stress insensitive. These data suggest that physical activity
can buffer the negative impact of stress on behavior and acquired immune fu
nction.