Clinical features of acute anaphylaxis in patients admitted to a university hospital: an 11-year retrospective review (1985-1996)

Background: Although anaphylaxis is considered a life-threatening event, th ere is a lack of information on the clinical characteristics at presentatio n, both in adults and in children. Objective: To describe in a nonselected population the clinical characteris tics and the treatments of acute anaphylaxis triggered by different agents. Methods: This is a retrospective review of the clinical features of 113 epi sodes of acute anaphylaxis resulting in admission to a university hospital. Initially, the 107 patients visited the emergency room and were then admit ted to the hospital. Results: Most anaphylactic events (63%) occurred at home. The most frequent symptoms involved the respiratory system (78%) and the skin (90%). Drugs, especially nonsteroidal anti-inflammatory drugs and antibiotics, were the m ost frequent cause of anaphylaxis in adults (49%). Patients with drug-induc ed anaphylaxis were older and more often had cardiovascular symptoms (hypot ension and tachycardia) (P = 0.0064). Hymenoptera venom was the second most frequent cause of anaphylaxis (29%). Most of the patients with hymenoptera venom anaphylaxis were male (80%) and more frequently they had no history of atopy (P = 0.012). In food-induced anaphylaxis, the cardiovascular syste m was less likely to be involved (P < 0.05) (39%). Seafood seems to be freq uently involved in food-induced anaphylaxis in our area. Specific immunothe rapy-induced anaphylaxis occurred more often in younger patients (P = 0.032 ). Epinephrine seems to be underused in Italy (only 15% of patients receive d it), especially for respiratory symptoms. Conclusions: Anaphylaxis triggered by different agents may have different c linical presentations and may occur in different types of patients. In Ital y, the inadequate use of epinephrine for anaphylaxis treatment needs to be publicized to both physicians and the general population.