Mitral valve replacement in small. children imposes significant clinical di
fficulties because of the relatively small mechanical prosthetic valves req
uired and the need for lifelong anticoagulation therapy. A child weighing 1
0.4 kg presented with thrombosis of her 19-mm mechanical mitral prosthesis
4 weeks after implantation despite appropriate oral anticoagulation therapy
. An emergency mitral valve replacement with a pulmonary autograft was succ
essfully performed with encouraging short-term results. (C) 2001 by The Soc
iety of Thoracic Surgeons.