Functional and biological test of a 20 channel implantable stimulator in sheep in view of functional electrical stimulation walking for spinal cord injured persons
M. Bijak et al., Functional and biological test of a 20 channel implantable stimulator in sheep in view of functional electrical stimulation walking for spinal cord injured persons, ARTIF ORGAN, 25(6), 2001, pp. 467-474
A newly developed implantable stimulator with 20 output channels, mainly in
tended for the stimulation of lower extremities in paraplegics, was implant
ed in 6 sheep over a time period of 26 weeks. Five epineural electrodes eac
h were used to contact various nerves at different locations to elicit hip
and knee extension and flexion and to make carrousel and selective stimulat
ion possible. Different electrode application strategies in view of paraple
gic standing and walking were investigated. Additional implanted electrodes
allowed M-wave monitoring for selectivity investigations in 3 sheep. Stimu
lator, electrode leads, and electrodes proved to be reliable. Selective sti
mulation with electrodes placed on the trunk of the sciatic nerve could be
demonstrated but with bad reproducibility. Histological investigation of th
e tissues surrounding electrodes and leads showed the expected stable forei
gn body response. Strong hip and knee extension could be gained in all case
s while only weak flexion forces could be elicited in most cases. Muscle bi
opsies showed that daily stimulation for 8 h at threshold level caused an i
ncrease in muscle Type I fibers and a decrease in Type IIc fibers. Implants
and electrodes fulfill the most important functional and biological criter
ia for their clinical application for paraplegic walking. The intention to
provide selective flexion functions via epineural stimulation could not be
demonstrated sufficiently in this animal model.