Synthesis of some thiazolo[3,2-b]-1,2,4-triazole-5(6H)-ones and their novel Michael addition products with anti-inflammatory activities

In this study, 21 new compounds having 2-methyl-6-benzylidenethiazolo [3,2- b]1,2,4-triazol 5(6H)-one (2-4) and 2-methyl-6- (alpha -aminobenzyl)thiazol o[3,2-b]-1,2,4-triazole-5-ol (2a-4g) structures were synthesized, The struc tures of the compounds were proved by spectral and elemental analysis. All of the compounds synthesized were tested for their anti-inflammatory activi y and ulcerogenic potential in mice at 10, 20 and 40 mg/kg dose Levels. Com pound 4b showed higher anti-inflammatory activity than the analogue derivat ives and indometacin (CAS 53-86-1), used as a reference drug, at 10 mg/kg d ose Level. Generally, the compounds were found to be more reliable than ind ometacin since they did not cause any reaction in the stomach.