Syntheses of curcumin bioconjugates and study of their antibacterial activities against beta-lactamase-producing microorganisms

In the present study cucumin bioconjugates, viz. di-O-glycinoylcurcumin (I) , di-O-glycinoyl-C-4-glycylcurcumin (II), 5'-deoxy-5'-curcuminylthymidine ( 5'-cur-T) (IV), and 2'-deoxy-2'-curcuminyluridine (2'-cur-U) (V) have been synthesized and characterized by elemental analysis and H-1 NMR. The turmer ic peptide (Tp) was isolated from the aqueous turmeric extract of the turme ric rhizome. The antibacterial activity of these four bioconjugates and als o of the turmeric peptide and sodium salt of curcumin (III) have been teste d particularly for beta -lactamase-producing microorganisms.