A. Lubinski et al., COMPARISON OF QT DISPERSION BETWEEN HYPERTROPHIC CARDIOMYOPATHY AND HYPERTENSIVE CARDIAC-HYPERTROPHY, HEARTWEB, 2(4), 1997, pp. 12-16
Patients (pts) with idiopathic hypertrophic cardiomyopathy (HCM) are t
hought to be at increased risk of sudden cardiac death. Recently, QT d
ispersion has been suggested to reflect dispersion in cardiac repolari
sation (DCR) which is responsible for occurrence of malignant ventricu
lar arrhythmias. The present study was performed to assess extent of D
CR in patients with HCM. In addition, DCR was assessed in the group of
patients with hypertensive left ventricular hypertrophy (LVH). Study
group consisted of 34 pts: 15 consecutive pts without cardiac diseases
and hypertension (control group), 11 pts with LVH and 8 pts with HCM.
To assess DCR in each patient in drug free condition duration of QT i
nterval was measured in 12 leads. Following parametres were calculated
: QT dispersion as a difference between maximal and minimal QT interva
l (QT diff.), standard deviation of QT intervals length (QTSD), QTc di
spersion as a difference between maximal and minimal QTc and QT interv
al ratio (QT dispersion/cycle length x 100%). Only patients with sinus
rhythm and absence of bundle branch block were included to study. All
measurements were performed by three investigators in a blind mode. Q
Tdiff was significantly greater in the LVH group when compared to cont
rol (58+/-21ms vs 32+/-2.3ms, p<0.01) and in the HCM group when compar
ed with the LVH group (77+/-26ms vs 58+/-21ms, p<0.01). Similar relati
ons were observed when QTSD was analyzed: (21+/-8ms vs 12+/-7ms, p<0.0
3) and (27+/-8ms vs 21+/-8ms, p<0,05) respectively. The QT interval ra
tio and QTc dispersion were greater in the LVH group when compared to
control (7+/-3% and 65+/-23 vs 4+/-3% and 36+/-28 respectively, p<0.01
) and greater in the HCM group than in LVH group: 8+/-3% vs 7+/-3%, p<
0.05 and 77+/-26 vs 65+/-23, p=0.07, respectivelly. Thus hypertrophy o
f the left ventricle leads to an increased dispersion of repolarisatio
n. More pronounced dispersion of repolarisation in HCM compared to LVH
may reflect structural abnormalities due to underlying disease, may i
ndicate additional risk of ventricular tachyarrhythmias in patients wi
th HCM.