Discovery and SAR of Org 24598 - A selective glycine uptake inhibitor

Authors
Brown, A Carlyle, I Clark, J Hamilton, W Gibson, S McGarry, G McEachen, S Rae, D Thorn, S Walker, G
Citation
A. Brown et al., Discovery and SAR of Org 24598 - A selective glycine uptake inhibitor, BIOORG MED, 11(15), 2001, pp. 2007-2009
Citations number
13
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
15
Year of publication
2001
Pages
2007 - 2009
Database
ISI
SICI code
0960-894X(20010806)11:15<2007:DASOO2>2.0.ZU;2-W
Abstract
The discovery of Org 24598, one of the first potent and selective inhibitor s of the glycine transporter is discussed. In vitro structure-activity rela tionships (SARs) data for interaction of a ligand with this system is discu ssed. (C) 2001 Elsevier Science Ltd. All rights reserved.