Design and synthesis of a highly selective EP4-receptor agonist. Part 2: 5-thia and 9 beta-haloPG derivatives with improved stability

Authors
Maruyama, T Asada, M Shiraishi, T Sakata, K Seki, A Yoshida, H Shinagawa, Y Maruyama, T Ohuchida, S Nakai, H Kondo, K Toda, M
Citation
T. Maruyama et al., Design and synthesis of a highly selective EP4-receptor agonist. Part 2: 5-thia and 9 beta-haloPG derivatives with improved stability, BIOORG MED, 11(15), 2001, pp. 2033-2035
Citations number
7
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
15
Year of publication
2001
Pages
2033 - 2035
Database
ISI
SICI code
0960-894X(20010806)11:15<2033:DASOAH>2.0.ZU;2-X
Abstract
Further chemical modification to identify more chemically stabilized EP4-re ceptor selective agonists was continued. As a result, a further two EP4-rec eptor selective agonists 5-thiaPGE(1) 2a, 10 and 9 beta -chloroPGF(2) analo gue 11 were discovered. (C) 2001 Elsevier Science Ltd. All rights reserved.