A novel method for the preparation of amino-substituted hypocrellin B

Authors
Xu, SJ Chen, S Zhang, M Shen, T
Citation
Sj. Xu et al., A novel method for the preparation of amino-substituted hypocrellin B, BIOORG MED, 11(15), 2001, pp. 2045-2047
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
15
Year of publication
2001
Pages
2045 - 2047
Database
ISI
SICI code
0960-894X(20010806)11:15<2045:ANMFTP>2.0.ZU;2-J
Abstract
A series of amino-substituted hypocrellins derived from hypocrellin B (HB) were synthesized by a novel mild method, in which the peri-hydroxylated per ylenequinone structure of hypocrellin was preserved by the reaction of HE w ith an amine. The red absorption of the resulting products was significantl y enhanced relative to the parent hypocrellins. which will significantly im prove its photodynamic therapy effectiveness. (C) 2001 Elsevier Science Ltd . All rights reserved.