Synthesis and photodynamic action of diphenyl-2,3-dihydroxychlorin: A potential tumor photosensitizer

Authors
Wang, TY Liu, HL Chen, JR Liu, FG Gu, Y Ma, JS
Citation
Ty. Wang et al., Synthesis and photodynamic action of diphenyl-2,3-dihydroxychlorin: A potential tumor photosensitizer, BIOORG MED, 11(15), 2001, pp. 2049-2052
Citations number
21
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
11
Issue
15
Year of publication
2001
Pages
2049 - 2052
Database
ISI
SICI code
0960-894X(20010806)11:15<2049:SAPAOD>2.0.ZU;2-F
Abstract
The synthesis, photophysical properties of diphenyl-2,3-dihydroxychlorin (D PCOH) and its photocytotoxicity to tumor cells are described. DPCOH exhibit s photodynamic activity in terms of type I and type II mechanisms under irr adiation. The quantum yield of O-1(2) in CHCl3 is 0.7. For the photocytotox icity to tumor cells, DPCOH proved to be 200 times more potent than HPD, an d the dark toxicity is low (dark IC90 > 32 mug/mL). (C) 2001 Elsevier Scien ce Ltd. All rights reserved.