ALKALOID FORMATION BY PENICILLIA OF THE SERIES FELLUTANA AND CANESCENTIA

The ability to synthesize fellutanines (earlier discovered in Penicill ium fellutanum cultures) and other tryptophan-containing alkaloids was shown in penicillia of the series Canescentia (P. canescens, P. melin ii, P. janzcewskii) and Fellutana (P. waksmanii and P. jensenii), belo nging to the section Divaricatum of the subgenus Furcatum of the genus Penicillium. Out of 26 strains studied in this work, four (P. canesce ns VKM F-1148, VKM F-1287, and VKM F-3108 and P. waksmanii VKM F-1027) produced fellutanine A or isofellutanine B metabolites typical of P. fellutanum, and seven strains (P. canescens VKM F-240, P. melinii VKM F-311, P. janzcewskii VKM F-2489, P. Jensenii VKM F-292 and VKM F-293, and P. waksmanii VKM F-682 and VKM F-1022) synthesized other tryptoph an-containing alkaloids-isorugulosuvine, meleagrin, glandicolin B, roq uefortine, 3,12-dihydroroquefortine, 16-N-ethylroquefortine, and ene)- 6-(1H-indole-3-yl-methyl)-2,5-piperazinediol.