Surgical treatment for skeletal breast cancer metastases - A population-based study of 641 patients

BACKGROUND, The objective of this article was to assess the occurrence of s ymptomatic bone metastases in a defined population of patients with breast carcinoma and to characterize the clinical outcome with reference to surgic al treatment for pathologic fracture or neurologic deficit. METHODS. The authors identified all patients in the Stockholm Breast Cancer Database (population base 1.8 million) with a diagnosis of bone metastases during 1989-1994. These cases were linked with the Stockholm County Counci l Hospital Discharge Diagnosis Registry that includes information on in-pat ient care and discharge diagnoses. This enabled us to identify patients who had undergone surgical treatment for their bony metastases at any of the s ix departments of orthopedics in the region, or who had been treated at the one department of neurosurgery. RESULTS, Six hundred forty-one patients with breast carcinoma presented wit h symptomatic skeletal metastasis during 1989-1994, and 107 (17%) were oper ated on. Metastases were located in long bones (77), spine (14), and pelvis (6). The median survival postoperatively was 6 months. The total reoperati on rate was 0.12. Hip screws and glide-screw plates were associated more of ten with failure as was location in the distal femur. Pain decreased postop eratively in 77% of the patients, and function improved in 65%. CONCLUSIONS, One in 10 patients with breast carcinoma developed symptomatic bone metastases, and one-fifth of these patients required surgery for path ologic fracture or neurologic deficit. There was a high failure rate in tho se hospitals in which few patients were operated on. (C) 2001 American Canc er Society.