The genetic algorithms (GAs) and simultaneous perturbation stochastic appro
ximation (SPSA), for the optimization of continuous distillation columns. B
oth the simple and azeotropic systems are considered in the analysis. In pa
rticular, for a specified degree of separation the problem of finding the o
ptimal values of: (i) the number of stages, (ii) reflux ratio (entrainer qu
antity in the case of azeotropic distillation), (iii) feed location(s), hav
e been addressed. The GA-based optimization has several attractive features
such as: (i) convergence to the global rather than to a local minimum, (ii
) the objective function need not satisfy smoothness, differentiability, an
d continuity criteria, (iii) robustness of the algorithm. The other optimiz
ation technique used in the study i.e., SPSA, is a rapid gradient-descent r
elated method for multivariate optimization and is especially well-suited i
n situations where direct computation of the objective function gradient is
not feasible, or the objective function measurements could be noisy. The f
easibility of utilizing the GA and SPSA techniques has been demonstrated by
considering the separation of three binary and two azeotropic systems of i
ndustrial relevance.