A general theoretical model of enthalpy-entropy compensation

Enthalpy-entropy compensation remains a mystery in chemistry and biophysics . Recent study suggested that the solvent reorganization might constitute t he physical origin of the compensation, which was unfortunately not widely applicable because compensation was also observed in solid phase reactions. In this study, a general theoretical model based upon strict mathematical deduction was presented, which indicated that the redistribution of the dis tinguishable subspecies might be the physical origin of the enthalpy-entrop y compensation in complex systems. As examples, the enthalpy-entropy compen sations in solvation and surface adsorption were discussed.