Haemoglobin Q-Thailand and hereditary spherocytosis in a Chinese family

Authors
Leung, KFS Au, WY Chan, AYY Chan, LC Waye, JS Chui, DHK Ma, SK
Citation
Kfs. Leung et al., Haemoglobin Q-Thailand and hereditary spherocytosis in a Chinese family, CLIN LAB H, 23(1), 2001, pp. 53-55
Citations number
18
Categorie Soggetti
Hematology
Journal title
CLINICAL AND LABORATORY HAEMATOLOGY
ISSN journal
01419854 → ACNP
Volume
23
Issue
1
Year of publication
2001
Pages
53 - 55
Database
ISI
SICI code
0141-9854(200102)23:1<53:HQAHSI>2.0.ZU;2-G
Abstract
A Chinese family with concurrent hereditary spherocytosis (HS) and haemoglo bin (Hb) Q-Thailand is described. The Hb Q-Thailand mutation was found on t he remaining alpha1 globin gene on a chromosome 16 containing the (-alpha ( 4.2)) deletion. Active haemolysis in members of this family is segregated w ith the HS phenotype, and the Hb Q-Thailand in the heterozygous state does not seem to show any modulating effect on HS.