J. Brabender et al., Epidermal growth factor receptor and HER2-neu mRNA expression in non-smallcell lung cancer is correlated with survival, CLIN CANC R, 7(7), 2001, pp. 1850-1855
The prognostic role of epidermal growth factor receptor (EGFR) and HER2-neu
remains controversial in patients with non-small cell lung cancer (NSCLC),
We studied the association between the mRNA expression of EGFR, HER2-neu,
and survival in primary tumor and matching nonmalignant tissues from 83 pat
ients with NSCLC, Analysis was performed using a quantitative real-time PCR
system (Taqman), EGFR and HER2-neu mRNA expression was detectable in all (
100%) specimens analyzed. Twenty-nine (34.9%) patients had high HER2-neu ex
pression, and 28 (33.7%) patients had high EGFR expression, A high HER2-neu
and EGFR coexpression was detectable in 14 (16.9 %) patients. High HER2-ne
u expression was associated with inferior survival (P = 0.004), whereas hig
h EGFR expression showed a trend toward inferior survival (P = 0.176), The
impact of HER2-neu and EGFR coexpression on patients ' survival was additiv
e (P = 0.003), Multivariate analysis determined high HER2-neu expression (P
= 0.041), and high EGFR/HER2-neu coexpression (P = 0.030) as significant a
nd independent unfavorable prognostic factors. These findings indicate that
HER2-neu and EGFR play a crucial role in the biological behavior of NSCLCs
, Testing of molecular marker coexpression (EGFR and HER2-neu) improves the
estimation of prognosis and appears to define low- and high-risk groups fo
r treatment failure in curatively resected NSCLC.