Lipid and mechano-gated 2P domain K+ channels

Citation
Aj. Patel et al., Lipid and mechano-gated 2P domain K+ channels, CURR OP CEL, 13(4), 2001, pp. 422-427
Citations number
44
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN CELL BIOLOGY
ISSN journal
09550674 → ACNP
Volume
13
Issue
4
Year of publication
2001
Pages
422 - 427
Database
ISI
SICI code
0955-0674(200108)13:4<422:LAM2DK>2.0.ZU;2-6
Abstract
The two pore domain K+ channels TREK and TRAAK are opened by membrane stret ch. The activating mechanical force comes from the bilayer membrane and is independent of the cytoskeleton. Emerging work shows that mechano-gated TRE K and TRAAK are opened by,various lipids,including long chain polyunsaturat ed anionic fatty acids and neutral cone-shaped: lysophospholipids. TREK-1 s hares the properties of the Aplysia neuronal S channel, a presynaptic backg round K+ channel involved in behavioral sensitization, a simple form of lea rning.