We describe a biopsy technique that is simple, rapid, and effective for num
erous cutaneous lesions. The inverted pyramidal biopsy (IPB) creates an acu
te geometric tissue defect with an apex located in the dermis. A cosmetical
ly pleasing result, while still providing adequate tissue to render a histo
logic description and diagnosis, is obtained. The technique can also be emp
loyed to remove a host of benign lesions, including dermatofibroma, fibrous
papules, and chalazion, among others.