Inflammatory bowel disease: Are there gender differences in the genetics of signal transduction? A preliminary study of cytosolic low molecular weight protein tyrosine phosphatase
N. Bottini et al., Inflammatory bowel disease: Are there gender differences in the genetics of signal transduction? A preliminary study of cytosolic low molecular weight protein tyrosine phosphatase, DIS MARKER, 16(3-4), 2000, pp. 163-166
The phenotype of cytosolic Low Molecular Weight Protein Tyrosine Phosphatas
e (cLMWPTP or ACP1), an enzyme involved in signal transduction of insulin,
PDGF and T-cell receptors, has been determined in 71 patients with Crohn's
Disease (CD:37 males and 34 females), 49 patients with Ulcerative Colitis (
UC: 27 males and 22 females) and 358 consecutive newborns (194 males and 16
4 females). cLMWPTP phenotypes showing a high concentration of F isoforms a
re associated with CD in females and with UC in males. Since PTPases counte
ract the effects of protein tyrosines kinases, a high concentration of F is
oform of cLMWPTP may influence the mucosal response to pathogenic factors,
increasing susceptibility to CD in females and to UC in males.