A phase II trial of oral eniluracil/5-fluorouracil in patients with inoperable hepatocellular carcinoma

Only a minority of patients with hepatocellular carcinoma (KCC) may benefit from curative treatments, whereas there is no standard therapy for the rem aining patients. The objective of this multicentre, open label phase II stu dy was to estimate the objective tumour response rate of a 28-day regimen o f oral eniluracil/5-fluorouracil (5-FU) in patients with chemotherapy-naive , or anthracycline-refractory, inoperable HCC. 45 patients received courses of twice daily oral 5-FU (1.0 mg/m(2)) and eniluracil (10 mg/ m(2)) for th e first 28 days of each 5-week course. Patients were assessed at regular in tervals to determine the tumour response and to evaluate toxicity. Patients were followed-up for a minimum of 6 months. No patient showed a partial or complete tumour response, and 18 patients (40%) had a best response of sta ble disease (95% confidence interval (CI) 25%, 55%). The median duration of progression-free survival (PFS) was 13.7 weeks (95% CI 10.0-20.0 weeks), a nd the median duration of overall survival (OS) was 50.3 weeks (range 1.1-6 4.1 + weeks). The combination of eniluracil/5-FU was well tolerated and had an acceptable safety profile. Only 7 patients (16%) reported at least one adverse event (AE) of grade 3 or 4 intensity considered reasonably attribut able to the study medication. In conclusion, oral eniluracil/5-FU had minim al, if any, activity in patients with inoperable HCC, but the safety profil e was acceptable. (C) 2001 Elsevier Science Ltd. All rights reserved.