Esters of chlorambucil with 2-substituted 1,4-dihydroxy-9,10-anthraquinones as multifunctional anticancer agents

Authors
Jin, GZ You, YJ Kim, Y Nam, NH Ahn, BZ
Citation
Gz. Jin et al., Esters of chlorambucil with 2-substituted 1,4-dihydroxy-9,10-anthraquinones as multifunctional anticancer agents, EUR J MED C, 36(4), 2001, pp. 361-366
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
ISSN journal
02235234 → ACNP
Volume
36
Issue
4
Year of publication
2001
Pages
361 - 366
Database
ISI
SICI code
0223-5234(200104)36:4<361:EOCW21>2.0.ZU;2-K
Abstract
Novel twelve esters of chlorambucil with 2-(1-hydroxyalkyl)-1,4-dihydroxy-9 ,10-anthraquinone were synthesized and tested for their antitumor activity in mice bearing S-180 ascitic cells as well as cytotoxic activity against L 1210 cells. Eight of them were highly cytotoxic on L1210 cells (ED50, <6 <m u>g mL(-1)) and derivatives 1 and 12 (T/C, 200 and 205%) appeared more acti ve in vivo than chlorambucil (T/C, 168%). (C) 2001 Editions scientifiques e t medicales Elsevier SAS.