A prospective evaluation of the Heidelberg retina flowmeter in diagnosing ischaemia following branch retinal vein occlusion: a masked, controlled comparison with fluorescein angiography
Dm. Squirrell et al., A prospective evaluation of the Heidelberg retina flowmeter in diagnosing ischaemia following branch retinal vein occlusion: a masked, controlled comparison with fluorescein angiography, EYE, 15, 2001, pp. 261-266
Purpose To evaluate the use of the Heidelberg retina flowmeter (HRF) in dia
gnosing retinal ischaemia following macular branch retinal vein occlusion.
Methods Ten patients with ischaemic macular branch retinal vein occlusion,
as determined by strict fluorescein angiographic criteria, were examined wi
th the HRF. Blood flow, blood volume and blood velocity characteristics fro
m areas of ischaemic and non-ischaemic retina were recorded and the results
between the normal and ischaemic areas of retina compared with paired t-te
st analysis. Ten healthy volunteers were similarly examined and acted as a
control group.
Results Compared with normal retina the HRF recorded a statistically signif
icant reduction in blood flow within the ischaemic retina in 7 of the 10 st
udy patients. In 2 patients the HRF actually recorded a statistically signi
ficant increase in blood flow in the area of ischaemic retina; there was no
significant difference in the blood flow recorded in the normal and ischae
mic retina in the remaining patient. HRF examination of the control group r
evealed a significant difference in the blood flow between two areas of app
arently normal retina in 3 of the 10 volunteers.
Conclusion The HRF is not a reliable tool for diagnosing retinal ischaemia
following branch retinal vein occlusion. Our results may suggest that the H
RF blood flow recordings are not derived from the retinal circulation alone
, but represent the cumulative blood flow through the combined circulations
of the retina and choriocapillaris.