Start-ups are one of the most relevant current subjects in wide sections of
academia, business and, in particular, in politics. This is due to many fa
ctors, some of which relate to new technological developments and their eco
nomic implications, to a general structural change and to the increasing im
portance, despite globalisation, of very small enterprises. This paper sets
forth arguments sustaining the thesis that the determinants for the establ
ishment of start-ups are not neutral in spatial terms. Rather, spatial diff
erentiation can be identified, systematised and, in principle, quantified w
ith regard to the causes as well as the economic effects of start-ups. Econ
omic geography in particular as an academic discipline is confronted with n
umerous new research tasks in the areas of theory, empirical research and p
olicy. Economic geography has comparative strengths over other disciplines
who also explore start-ups, which should be emphasised more emphatically an
d with more self-confidence than to date.