The prognostic value of quality of life scores during treatment for oesophageal cancer

Background - Quality of life (QL) data are useful to evaluate the effective ness of treatment. Accumulating evidence suggests that QL data may predict survival. Aims - In this study we investigated if baseline QL scores and changes in Q L scores before and after intervention are prognostic for patients with oes ophageal cancer. Patients - Between 1993 and 1995, 92 consecutive new patients with oesophag eal cancer were studied; 89 were followed until death or the end of the stu dy period (survival of seven patients was censored in May 1999). Methods - All patients completed the European Organisation for Research and Treatment of Cancer (EORTC) core questionnaire (EORTC QLQ-C30) and the dys phagia scale of the oesophageal module (EORTC QLQ-OES24) before treatment a nd at regular intervals throughout the study. Cox's proportional hazards mo dels assessed the impact of baseline QL variables and changes in QL scores on survival. Results - Cox's proportional hazards models, adjusting for associations bet ween QL scores, age, and TNM stage, found that physical function at baselin e was significantly associated with survival (p=0.002). An increase in phys ical function score of 10 points corresponded to a 12% reduction in the lik elihood of death at any given time (95% confidence intervals 4-18%). Furthe r exploratory multivariable analyses suggested that improvement in emotiona l function six months after treatment was significantly related to longer s urvival (p <0.0001), Conclusions - These data provide evidence to support a relationship between patient rated scores of QL and survival. Further understanding of the asso ciations between QL and clinical variables is needed.