Quantitative estimation of blood velocity using Doppler techniques is funda
mentally limited because only the axial component can be detected. Speckle
decorrelation resulting from scatterer motion may be used to compute non-ax
ial components and to obtain quantitative flow information. Based on both s
imulations and experimental results, it is shown that the decorrelation tec
hnique is feasible only for constant flows. If flow gradients are present,
the correlation between two signals along the same line of observation may
be significantly affected by the gradients. Therefore, the decorrelation me
thod cannot be used for quantitative flow estimation if flow gradients are
not accurately measured and effects on signal correlation are not fully com
pensated. Results in this paper show that accurate estimation of flow gradi
ents is practically difficult. It is further shown that effects of signal-t
o-noise ratio (SNR) on the correlation must also be taken into account for
quantitative flow analysis.